What if the world's most widely used medicines could work better?
CV6 Therapeutics is a clinical-stage Genomic Uracil Stress Response (GUSR) platform company developing specific, first-in-class medicines for cancer and inflammatory diseases.
Lead program CV6-168 is currently in Phase 1a clinical development.
Amplifying Cornerstone Cancer Therapies
Thymidylate synthase (TS) inhibitors such as 5-fluorouracil (5-FU) anchor cancer care. Methotrexate anchors rheumatoid arthritis care. Both disrupt nucleotide metabolism, and CV6 medicines are designed to exploit the stress they create.
In cancer, CV6-168 blocks dUTPase to drive uracil into tumor DNA, inducing lethal genomic stress and, in preclinical studies, innate immune signaling. It is being evaluated in an ongoing Phase 1a trial in combination with infusional 5-FU, with no dose-limiting toxicities observed to date.
In rheumatoid arthritis, CV6-1271 applies the same biology alongside methotrexate and is in preclinical development.
Therapies such as 5-FU, capecitabine and pemetrexed are used across first-line, second-line and maintenance treatment in colorectal, breast, gastric, pancreatic, lung, and head and neck cancers.
Methotrexate is the first-line standard of care in rheumatoid arthritis, yet around half of patients respond inadequately.
Each year, approximately 4.8 million newly diagnosed cancer patients receive a TS-directed therapy at some point during their treatment.
Global Cancer Incidence is Rising
Global cancer incidence is projected to approach 30 million cases annually by 2040, representing an increase of approximately 47 percent from 2020 levels, based on GLOBOCAN estimates.
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CV6 Therapeutics Founder Shortlisted for Business Post CEO of the Year Award
Dr. Robert D. Ladner has been shortlisted alongside nine business leaders from across the island of Ireland after building CV6 into a GUSR platform company whose first-in-class lead oncology candidate is advancing through a first-in-human Phase 1a clinical trial.
AIB Business Eye Award Nominations Recognise CV6 Innovation, Growth and Leadership
Organized by Northern Ireland business magazine Business Eye in partnership with AIB, the awards are marking their 20th year of recognizing achievement, innovation and leadership across the region’s business community.
HIRANI Spotlights CV6’s Belfast Biotechnology Story
From Discovery to Clinical Development: CV6 grew from an original scientific idea into a clinical-stage biotechnology company, the Northern Ireland ecosystem supporting that journey, and the company’s work across cancer and inflammatory disease.